Table 1 Genotype distribution and allele frequencies of FOXO3 polymorphisms in longevity and control subjects
SNP | M/ma | Group | MM | Mm | mm | p HWE b | MAFc | p allele d | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
rs2802288 | G/A | Longevity | 199 (0.39) | 233 (0.46) | 74 (0.15) | 0.666 | 0.38 | 0.005 | 1.266 (1.075 − 1.491) |
Control | 374 (0.45) | 376 (0.45) | 80 (0.10) | 0.300 | 0.32 | ||||
rs2802290 | A/G | Longevity | 220 (0.43) | 235 (0.46) | 51 (0.10) | 0.306 | 0.33 | 0.589 | 1.147 (0.887 − 1.236) |
Control | 373 (0.45) | 378 (0.46) | 79 (0.10) | 0.232 | 0.32 | ||||
rs2802292 | T/G | Longevity | 205 (0.41) | 246 (0.49) | 54 (0.11) | 0.116 | 0.35 | 0.026 | 1.207 (1.022 − 1.424) |
Control | 393 (0.47) | 361 (0.43) | 76 (0.09) | 0.565 | 0.31 | ||||
rs2764264 | T/C | Longevity | 199 (0.39) | 245 (0.48) | 62 (0.12) | 0.312 | 0.36 | 0.009 | 1.244 (1.055 − 1.467) |
Control | 383 (0.46) | 370 (0.45) | 77 (0.09) | 0.359 | 0.32 | ||||
rs7341233 | T/C | Longevity | 350 (0.69) | 135 (0.27) | 21 (0.04) | 0.089 | 0.17 | 0.565 | 0.942 (0.768 − 1.155) |
Control | 548 (0.66) | 259 (0.31) | 23 (0.03) | 0.245 | 0.18 | ||||
rs13217795 | T/C | Longevity | 210 (0.42) | 236 (0.47) | 60 (0.12) | 0.610 | 0.35 | < 0.001 | 1.358 (1.149 − 1.605) |
Control | 417 (0.50) | 352 (0.42) | 61 (0.07) | 0.658 | 0.29 | ||||
rs3800231 | G/A | Longevity | 213 (0.42) | 235 (0.46) | 58 (0.11) | 0.573 | 0.35 | 0.013 | 1.235 (1.046 − 1.459) |
Control | 401 (0.48) | 359 (0.43) | 70 (0.08) | 0.409 | 0.30 |
