Table 2 Characteristics of studies of rs2802288 and rs2802292 in FOXO3 included in the meta-analysis

Study	Population	longevity group			control group			Genotype Methods	Significance^c
Study	Population	Age range (years)	M^a	m^b	Age range (years)	M^a	m^b	Genotype Methods	Significance^c
rs2802292 (T/G)
Anselmi CV (2009)⁵	Europeans	90–108	233	245	18–48	204	140	Imputation	Yes
Soerensen M (2010)⁶	Europeans	92–93	1352	826	NA	949	523	GoldenGate	No
Willcox BJ (2008)³	Asians	95–106	268	158	73–81	599	205	TaqMan	Yes
Li Y (2009)⁸	Asians	102.3 ± 0.14^d	1062	460	47.1 ± 0.22^d	1605	507	Sanger sequencing	Yes
Li XJ (2010)⁹	Asians ^c	90–110	229	125	48–89	214	82	TaqMan	Yes
This study	Asians	80–105	656	354	30–75	1147	513	PCR-HRM	Yes
rs2802288 (G/A)
Kuningas M (2007)²⁶	Europeans	88–92	866	498	27–36	478	262	MALDI-TOF	No
Flachsbart F (2009)⁴	Europeans	95–110	1202	860	60–75	899	563	TaqMan	No
Flachsbart F (2009)⁴	Europeans	> = 100	477	299	60–75	899	563	TaqMan	Yes
Anselmi CV (2009)⁵	Europeans	90–109	475	485	18–48	362	308	BeadChip	No
Li XJ (2010)⁹	Asians	90–110	227	127	48–89	213	83	TaqMan	Yes
This study	Asians	80–105	631	381	30–75	1124	536	PCR-HRM	Yes

^aM = major allele, corresponding to rs2802292*T and rs2802288*G; ^b m = minor allele, corresponding to rs2802292*G and rs2802288*A; ^c comparisons based on allele-contrast model;^d means ± standard error

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