Figure 7
From: TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway
Proposed mechanisms by which TIGAR regulates DNA damage.
TIGAR functions to lower Fru-2,6-P2 levels and upregulate G6PD in cells, resulting in an inhibition of glycolysis and enhancement of the PPP to produce NADPH and ribose-5-phosphate. TIGAR reduces DNA damage and enhances DNA repair through increasing generation of NADPH which decreases intracellular ROS levels and ribose which provides materials for synthesis of nucleotides. TIGAR also promotes DNA repair by increasing phosphorylation of ATM through Cdk5. Thus TIGAR favors cancer cell survival by increasing stability of DNA.
