Figure 4 | Scientific Reports

Figure 4

From: Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel

Figure 4

Solution structures of BmKTX-19 and BmKTX-196 peptide blockers.

A, NMR-derived solution structure of BmKTX-19 (PDB code: 2MLA). The Cα traces (gray) of 20 structures of BmKTX-19 are superimposed. The side chains for cysteine residues and disulfide bonds are shown in yellow. B, Superimposition of the BmKTX-19 (green) structure with that of BmKTX (red, PDB code: 1 BKT). C, Superimposition of the BmKTX-19 (green) structure with that of ADWX-1 (blue, PDB code: 2K4U). D, NMR-derived solution structure of BmKTX-196 (PDB code: 2MLD. The Cα traces (gray) of 20 structures of BmKTX-196 are superimposed. The side chains for cysteine residues and disulfide bonds are shown in yellow. E, Superimposition of the BmKTX-196 (green) structure with that of BmKTX (red, PDB code: 1 BKT). F, Superimposition of the BmKTX-196 (green) structure with that of ADWX-1 (blue, PDB code: 2K4U).

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