Figure 6 | Scientific Reports

Figure 6

From: Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel

Figure 6

Distinct interaction modes between toxins and Kv1.3 channels mediated by the different distributions of toxin acidic residues.

A, Interaction of BmKTX-19 with the Kv1.3 channel. B, Interaction of BmKTX-196 with the Kv1.3 channel. C, Interaction of ADWX-1 with the Kv1.3 channel, which is similar with the classical Lys26-blocking mode between BmKTX-D33H and Kv1.3 channel10,22. D, Interaction of BmKTX with the Kv1.3 channel22. Toxin acidic residues and key functional residues were marked.

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