Figure 1 | Scientific Reports

Figure 1

From: Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway

Figure 1

Mutations in KRAS/NRAS/BRAF conferred resistance to EFGR inhibitors.

Reproduction of the Genomics of Drug Sensitivity in Cancer (GDSC) database generating the volcano plots. Green and red circles respectively encompassing sensitive and resistant cells with certain mutated gene passing 20% false discovery rate (FDR) with size of the circles indicating cell line numbers, showing mutations in KRAS/NRAS/BRAF conferred resistance to A) Gefitinib and dual EGFR/ERBB2 inhibitor and B) Afatinib in a variety of cancer cells.

Back to article page