Figure 4
From: Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway
Combination of EGFR and PPP inhibitors exert synergistic effect in triple WT MM cells.
Both A) cell proliferation and B) migration were significantly supressed with drug combination (both treated at 5 μM of dose for 48 h); C) Combination with EGFR/ERBB2 dual inhibitor Afatinib (5 μM) also showed synergistic effects; D) The inhibition by combination treatment was recovered almost completely by supplement of NADPH.
