Table 2 Normalized least-squares error for the best fit of model types to the binding curves for AT1R-H8 binding to lipid bilayers at 10 μM peptide concentration.

From: Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion

Lipid composition

2-state

2-state + expansion

2-state + expansion + lag

2-state + expansion + threshold

3-state

3-state + expansion

3-state + expansion + lag

3-state + expansion + threshold

DMPC

0.389

0.356

0.356

 

0.249

0.177

0.177

 

DMPC/DMPS (80:20)

0.105

0.104

0.103

 

0.085

0.056

0.056

 

DMPC/DMPS/PI(4)P (76:20:4)

2.168

2.168

1.545

0.919

1.554

0.796

0.319

0.303

DMPC/DMPS/PI(4,5)P2 (76:20:4)

0.837

0.422

0.367

0.422

0.756

0.375

0.153

0.169

  1. “Expansion” refers to the use of bilayer expansion in the model, “Lag” refers to the use of the birefringence-lag model; “Threshold” refers to the use of the mass-threshold model.
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