Table 2 The circadian rhythm characteristics of Per2, p53, Cyclin D1, CDK1 and Cyclin B1 mRNA in groups I, II and III.

From: Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa

Gene

Tissue

Mesor

Amplitude

Acrophase(HALO)

Peak value

Trough value

P -value

Per2

I

1.51

0.77

16.07

2.29

0.73

0.0009

 

II

1.04

0.52

13.13

1.56

0.52

0.001

 

III

0.96

0.58

15.53

1.53

0.38

0.0003

p53

I

3.34

1.92

20.47

5.26

1.42

0.0032

 

II

2.33

0.86

23.87

3.19

1.47

0.007

 

III

1.27

0.45

21.06

1.72

0.83

0.0021

Cyclin D1

I

1.42

0.75

17.20

2.17

0.61

0.0001

 

II

1.80

0.33

23.80

2.13

1.47

0.0449

 

III

2.69

0.37

17.07

3.06

2.32

0.003

CDK1

I

3.00

2.14

6.11

5.14

0.86

0.0004

 

II

4.51

3.54

2.79

8.05

0.97

0.007

 

III

4.77

2.77

19.87

7.54

2.00

0.000

Cyclin B1

I

1.35

0.91

1.66

2.26

0.44

0.0036

 

II

—

—

—

—

—

0.9299

 

III

2.55

0.93

20.13

3.48

1.62

0.0079

  1. The circadian rhythm is described by the mesor, amplitude and acrophase. A value of P < 0.05 indicates that the mRNA expression shows a circadian rhythm. (I: normal mucosa, II: precancerous lesion and III: carcinoma; HALO: hour after light onset).
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