Figure 4
From: Cocaine-mediated impact on HIV infection in humanized BLT mice
Increased activation persists in the cocaine treated, HIV infected animals.
Splenocytes from the sacrificed mice were also used for flow cytometric analysis of lymphocyte phenotype. The COCAINE-HIV group of mice has higher levels of (a) CD4CD38 and (b) CD8CD38. (c) To assess functionality of CD8 T cells, we stimulated ex vivo splenocytes in the presence of GolgiPlug to measure levels of IFN-γ production. The COCAINE-HIV group had comparable levels to HIV despite the higher numbers of CD8CD38 T cells. For all figures, *p < 0.05, **p < 0.01, using Mann-Whitney or Kruskal-Wallis test (for 3 or more groups).
