Figure 5
From: Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling
Schematic of the model. Together with our previous study, we demonstrates a model of how PLGF affects metastasis of LC. LC cells not only produce PLGF to activate MMP3 through an autologous way via ERK/MAPK signaling pathway, but also secretes PLGF to polarize macrophages into TAM in a TGFβ-receptor-signaling-dependent manner, which subsequently activates MMP9 in TAM. Both MMP3 from LC cells and MMP9 from TAM enhance cancer metastasis.
