Figure 5 | Scientific Reports

Figure 5

From: Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

Figure 5

Combined treatment of saporin-encapsulated exosomes with cationic lipids and GALA peptide effectively induces cytotoxicity.

(a) Microscopic observation of HeLa cells treated with saporin-encapsulated exosomes (20 μg/ml) in the presence or absence of Lipofectamine LTX (2% (v/v)) and GALA peptide (2 μM) for 24 hr at 37 °C. Scale bar: 200 μm. (b) Cytotoxicity of HeLa cells treated with saporin-encapsulated exosomes (20 μg/ml) or exosomes (20 μg/ml) without saporin in the combination treatment of Lipofectamine LTX and GALA peptide under the same experimental conditions as (a), analysed by the WST-1 assay. The data are the averages (±SD) of three experiments.

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