Table 3 Adjusted HRs for dementia in the OA and non-OA cohorts determined using the frailty model.

From: Osteoarthritis Increases the Risk of Dementia: A Nationwide Cohort Study in Taiwan

Presence of dementia during the 4-year follow-up period

 

Crude HR (95% CI)

Adjusted HR (95% CI)

P value for adjusted HR

OA

1.32 (1.17–1.49)

1.21 (1.07–1.38)

0.002

Age (year)

1.09 (1.08–1.10)

1.08 (1.07–1.09)

<0.001

Sex (M)

0.90 (0.79–1.02)

0.73 (0.65–0.83)

<0.001

Autoimmune disease

1.22 (0.95–1.55)

1.14(0.90–1.46)

0.299

DM

1.73 (1.53–1.96)

1.25 (1.10–1.42)

<0.001

Hypertension

2.57 (2.24–2.95)

1.06 (0.92–1.23)

0.381

Hyperlipidaemia

0.98 (0.86–1.12)

0.92 (0.80–1.05)

0.218

Coronary heart disease

1.85 (1.63–2.09)

0.94 (0.82–1.07)

0.342

Parkinson’s disease

8.44 (7.26–9.82)

2.98 (2.54–3.49)

<0.001

COPD

2.15 (1.91–2.42)

1.27 (1.12–1.44)

<0.001

Stroke

6.58 (5.83–7.43)

3.14 (2.75–3.58)

<0.001

  1. To adjust for the hospital cluster random effect, we proposed the frailty model.