Figure 4 | Scientific Reports

Figure 4

From: Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis

Figure 4

Effect of targeted estrogen delivery on glucose and insulin homeostasis in WT mice.

(A) Fed blood glucose and (B) fed serum insulin in male WT mice treated with aGLP1 (120 μg/kg), iGLP1-E2 (120 μg/kg) or aGLP1-E2 (120 μg/kg) for 48 hours. (C) Fasting blood glucose and (D) fasting serum insulin in the same mice. (E) HOMA-IR calculated from C and D. (F) IP-ITT (0.75 U/kg) in male WT mice treated as above. (G) Fasting serum glucagon and (H) fed serum glucagon in male WT mice from A and B. N = 10 mice per group. Results represent the mean ± SEM. * vs. Vehicle when not indicated. *≤0.05, **≤0.01, ***≤0.001.

Back to article page