Figure 1
From: CART treatment improves memory and synaptic structure in APP/PS1 mice
CART immunoreactivity is prominent in cortical Aβ plaques in AD.
(a) CART immunostaining is distributed uniformly in cell bodies of cortical neuron-like cells in a control non-AD patient (i) and concentrated around the cores of Aβ plaque-like structures in AD brain (representative of three non-AD and three AD brains) (ii) and in 10-month-old APP/PS1 transgenic mice (iii). Scale bar =100 μm. (b) Similar staining patterns for CART (green) and Aβ (red) are seen in 8-month-old APP/PS1 mice, where the CART signal was most prominent in the regions surrounding the plaques but not at the core of the plaques (indicated by white arrows). Scale bar =100 μm. The images are representatives of 3 mice per phenotype with similar results.
