Figure 6
From: CART treatment improves memory and synaptic structure in APP/PS1 mice
CART treatment facilitated functional recovery of synapses in APP/PS1 mice.
Electrophysiological determination of deficits in Schaffer collateral-CA1 synaptic transmission and the induction of long-term potentiation. (a) A plot showing input/output (I/O) curves in response to stimulus (0.1-1.1 mA) at the hippocampal CA1 region of B6 control mice, APP/PS1 mice and APP/PS1 mice receiving CART treatment (8 months old). The I/O curve was measured by averaging the slope of EPSPs against stimulus intensity at 0.1-1.1 mA. The slope of the regression line for the I/O curve in APP/PS1 mice was markedly reduced. With CART treatment, the reduction in I/O curve slope was significantly improved for APP/PS1 mice. All values are expressed as mean ± SEM from 6 mice in each group. *p < 0.05 versus B6 control mice, #p < 0.05 versus APP/PS1+CART. The capacity to establish long-term potentiation (LTP) from high-frequency stimulus (HFS, 100 pulses at 100 Hz) with the same pre-HFS intensity at hippocampal CA1 region of B6 control mice (b), APP/PS1 transgenic mice (c) and APP/PS1 mice with CART treatment (d).
