Table 3 Meta-analysis of the association between the TNF-α-308G > A polymorphism and BC in Caucasians and Asians (dominant model)
Ethnicity | Study (n) | Samples (cases/controls) | Cases | Controls | PHWE (controls) | OR (95% CI) | P | I2 (%) | P het | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | GA | AA | GG | GA | AA | ||||||||
Caucasian | 13 | 11448/13176 | 8178 | 2919 | 351 | 9260 | 3586 | 330 | 0.437 | 1.06 (0.88–1.27) | 0.555 | 80.7 | <0.001 |
Asian | 5 | 2119/1911 | 1870 | 241 | 8 | 1711 | 279 | 8 | 0.345 | 1.07 (0.58–1.96) | 0.826 | 88.7 | <0.001 |
Overall | 18 | 13567/15087 | 10048 | 3160 | 359 | 10971 | 3865 | 338 | 0.912 | 1.04 (0.87–1.24) | 0.653 | 82.7 | <0.001 |
