Table 4 Clinicopathological features of BC patients classified by IHC subtype and TNF-α-308 polymorphism.
Characteristics | All BC (n= 768) | TNBC (n= 163) | Her2+ (n= 82) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | GA+AA | OR (95% CI) | P | GG | GA+AA | OR (95% CI) | P | GG | GA+AA | OR (95% CI) | P | |
Age (years) | ||||||||||||
≤45 | 369 | 43 | 1.00 | 49 | 8 | 1.00 | 18 | 5 | 1.00 | |||
>45 | 399 | 57 | 0.89 (0.58–1.37) | 0.604 | 98 | 8 | 0.50 (0.18–1.41) | 0.184 | 53 | 6 | 0.41 (0.11–1.50) | 0.167 |
Body mass index (kg/m2) | ||||||||||||
≤25 | 353 | 54 | 1.00 | 81 | 13 | 1.00 | 38 | 5 | 1.00 | |||
>25 | 321 | 37 | 0.75 (0.48–1.18) | 0.211 | 72 | 4 | 0.35 (0.11–1.11) | 0.064 | 33 | 6 | 1.38 (0.39–4.95) | 0.618 |
Tumour stage | ||||||||||||
I+II | 375 | 47 | 1.00 | 80 | 7 | 1.00 | 31 | 4 | 1.00 | |||
III+IV | 393 | 44 | 1.20 (0.77–1.86) | 0.419 | 67 | 10 | 1.71 (0.62–4.73) | 0.300 | 40 | 7 | 1.36 (0.36–5.05) | 0.649 |
Tumour size (cm) | ||||||||||||
≤5 | 547 | 69 | 1.00 | 112 | 14 | 1.00 | 52 | 6 | 1.00 | |||
>5 | 72 | 10 | 1.10 (0.54–2.23) | 0.790 | 17 | 1 | 0.47 (0.06–3.81) | 0.470 | 10 | 1 | 0.87 (0.09–8.00) | 0.900 |
Lymph node metastasis | ||||||||||||
No | 275 | 35 | 1.00 | 70 | 6 | 1.00 | 29 | 5 | 1.00 | |||
Yes | 385 | 55 | 1.12 (0.72–1.76) | 0.616 | 79 | 10 | 1.48 (0.51–4.27) | 0.470 | 32 | 6 | 1.09 (0.30–3.95) | 0.898 |
Distant metastasis | ||||||||||||
No | 617 | 74 | 1.00 | 125 | 10 | 1.00 | 66 | 11 | 1.00 | |||
Yes | 56 | 10 | 1.49 (0.73–3.04) | 0.272 | 23 | 7 | 3.80 (1.31–11.02) | 0.009 | 5 | 0 | NA | |
Age at menarche (years) | ||||||||||||
≤15 | 415 | 70 | 1.00 | 103 | 11 | 1.00 | 39 | 10 | 1.00 | |||
>15 | 228 | 22 | 0.57 (0.35–0.95) | 0.029 | 47 | 5 | 1.00 (0.71–1.42) | 0.995 | 29 | 3 | 0.40 (0.10–1.60) | 0.186 |
Menopause | ||||||||||||
Yes | 423 | 54 | 1.00 | 72 | 8 | 1.00 | 37 | 5 | 1.00 | |||
No | 224 | 33 | 1.15 (0.73–1.83) | 0.543 | 74 | 7 | 0.85 (0.29–2.47) | 0.767 | 31 | 5 | 1.19 (0.32–4.51) | 0.794 |
Family history of cancer | ||||||||||||
No | 531 | 75 | 1.00 | 118 | 11 | 1.00 | 53 | 10 | 1.00 | |||
Yes | 140 | 20 | 1.01 (0.60–1.71) | 0.966 | 30 | 4 | 1.43 (0.43–4.81) | 0.561 | 14 | 3 | 1.14 (0.28–4.69) | 0.860 |
Characteristics | Luminal A (n = 183) | Luminal B (n = 340) | ||||||
|---|---|---|---|---|---|---|---|---|
GG | GA+AA | OR (95% CI) | P | GG | GA+AA | OR (95% CI) | P | |
Age (years) | ||||||||
≤45 | 73 | 8 | 1.00 | 129 | 22 | 1.00 | ||
>45 | 92 | 10 | 0.99 (0.37–2.64) | 0.987 | 156 | 33 | 1.24 (0.69–2.23) | 0.472 |
Body mass index (kg/m2) | ||||||||
≤25 | 90 | 12 | 1.00 | 144 | 24 | 1.00 | ||
>25 | 75 | 6 | 0.60 (0.22–1.68) | 0.326 | 141 | 21 | 0.89 (0.48–1.68) | 0.726 |
Tumour stage | ||||||||
I+II | 104 | 11 | 1.00 | 160 | 25 | 1.00 | ||
III+IV | 61 | 7 | 1.09 (0.40–2.95) | 0.873 | 125 | 20 | 1.02 (0.54–1.93) | 0.941 |
Tumour size (cm) | ||||||||
≤5 | 136 | 17 | 1.00 | 247 | 32 | 1.00 | ||
>5 | 10 | 1 | 0.80 (0.10–6.64) | 0.836 | 35 | 7 | 1.54 (0.63–3.76) | 0.336 |
Lymph node metastasis | ||||||||
No | 77 | 7 | 1.00 | 99 | 17 | 1.00 | ||
Yes | 88 | 11 | 1.38 (0.51–3.72) | 0.529 | 186 | 25 | 1.90 (0.79–4.55) | 0.144 |
Distant metastasis | ||||||||
No | 153 | 17 | 1.00 | 273 | 36 | 1.00 | ||
Yes | 11 | 1 | 0.82 (0.10–6.73) | 0.852 | 17 | 2 | 0.89 (0.20–4.02) | 0.882 |
Age at menarche (years) | ||||||||
≤15 | 110 | 14 | 1.00 | 163 | 35 | 1.00 | ||
>15 | 53 | 4 | 0.59 (0.19–1.89) | 0.372 | 99 | 10 | 0.52 (0.25–1.07) | 0.070 |
Menopause | ||||||||
Yes | 99 | 11 | 1.00 | 215 | 30 | 1.00 | ||
No | 51 | 7 | 1.24 (0.45–3.38) | 0.680 | 68 | 14 | 1.48 (0.74–2.94) | 0.267 |
Family history of cancer | ||||||||
No | 117 | 15 | 1.00 | 243 | 39 | 1.00 | ||
Yes | 45 | 6 | 1.04 (0.38–2.85) | 0.939 | 51 | 7 | 1.21 (0.51–2.84) | 0.513 |
