Figure 10
SL327 administration at P6, but not at P14, induced social deficits later in adulthood.
(a–c) SL327 administration at P6 induced social deficits when assessed at 11 weeks of age (control: n = 13, SL327: n = 14). (a) Social behavior was assessed by the sociability test. When exposed to caged social and inanimate targets, controls exhibited a normal preference for the social target over an inanimate target, whereas mice with SL327 administration exhibited no significant preference. Furthermore, these mice spent significantly less time interacting with the social target compared with vehicle controls. (b) Mice treated with SL327 did not show significant differences from controls in latency to find a buried treat after overnight food deprivation. (c) Time spent interacting with a novel inanimate object was not significantly affected by SL327 treatment. (d–f) SL327 administration at P14 did not induce social deficits when assessed at 11 weeks of age (control: n = 12, SL327: n = 14). (d) Mice treated with SL327 exhibited normal behavior in the sociability test. (e) Latency to find a buried treat after overnight food deprivation. (f) Time spent interacting with a novel inanimate object. Data are represented as mean ± SEM. **P < 0.01, ***P < 0.001.
