Figure 5 | Scientific Reports

Figure 5

From: Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

Figure 5

Quantification confirmed the significant increase of apoptosis in the brain from mice administered SL327 at P6 compared with vehicle controls.

Numbers of cleaved caspase-3 positive cells. (a) CA1 = hippocampal CA1 region, (b) CA3 = hippocampal CA3 region, (c) DG = dentate gyrus, (d) Sub = subiculum, (e) Amg = amygdala, (f) CP = caudate/putamen, (g) Th = thalamus, (h) RSC = retrosplenial cortex, (i) II = cortex layer II in parietal cortex, (j) V = cortex layer V in parietal cortex. Data are represented as mean ± SEM (n = 5 mice for each). **P < 0.01, ***P < 0.001.

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