Figure 3 | Scientific Reports

Figure 3

From: Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer

Figure 3

Iturin A induces apoptosis as measured by DNA laddering and western blot analysis.

(A) DNA fragmentation by agarose gel electrophoresis in MDA-MB-231 and MCF-7 cells treated with Iturin A. (B) Western blot analysis of proapoptotic and anti-apoptotic proteins in MDA-MB-231 and MCF-7 cells treated with Iturin A for 12, 24 and 48 h. Blots were cut and cropped according to the molecular weight of the proteins. (C) and (D) Densitometric plot of proapoptotic and antiapoptotic proteins of MDA-MB-231 and MCF-7 cells treated with Iturin A. Each bar represents average arbitrary pixel of three experiments.

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