Figure 7
Anti-tumor activity of Iturin A in MDA-MB-231 human breast cancer xenografts.
Nude mice bearing MDA-MB-231 xenografts treated with Iturin A (5 and 10 mg/kg). (A) Tumor bearing nude mice and excised tumors at the end of experiment. (B, C) Excised tumor volume (mm3) and mass (gm) are shown by representative bar graph. Significance level is represented by *P<0.05, **P<0.01, ***P<0.001. (D) TUNEL assay and immunohistochemistry of Ki-67, CD-31, P-Akt (Ser 473 and Thr 308) and T-Akt are performed from excised tumors tissue samples. (E) Immunohistochemitry of P-GSK3β, T-GSK3β, P-FoxO3a, T-FoxO3a, P-MAPK and T-MAPK.
