Figure 6
From: Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Sunitinib inhibits mouse retinoblastoma invasion and metastasis.
(a) SJmRBL-8 retinoblastoma cells were intravitreally implanted in zebrafish and sunitinib was added to the aquarium water to constitute a final concentration of 1 μM. Retinoblastoma invasion and metastasis were monitored at different time points. Arrows point to metastatic tumor cells. Bar = 100 μm. (b) Quantification of metastatic tumor cells and the averages of maximal distance of metastatic foci in vehicle- and sunitinib-treated zebrafish embryos (n = 60 embryos/group).
