Figure 3 | Scientific Reports

Figure 3

From: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy

Figure 3

Inhibitory effects of ADTM on ADP-and AA-induced platelet aggregation in vitro.

Platelets were pretreated with or without the indicated concentrations of the tested compounds, ADTM (1–100 μM), DSS (100 μM), TMP (100 μM), aspirin (1–100 μM) and clopidogrel (1–100 μM) for 5 min at 37 °C and the percentage (%) of platelet aggregation inhibition normalized to DMSO treated samples (vehicle control) was determined as described in Materials and Methods. The platelets were stimulated with ADP (a) and AA (b). Data are expressed as mean ± SD, *P < 0.01 compared with the 100 μM DSS group. #P < 0.01 compared with the 100 μM TMP group, &P < 0.01 compared with the 100 μM DSS + TMP group, n ≥ 3/group. D = DSS, T = TMP, ASA = aspirin, clop = clopidogrel.

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