Table 2 Summary ORs (95% CI) for TRAIL-R1 Thr209Arg and cancer.
From: Genetic association between TRAIL-R1 Thr209Arg and cancer susceptibility
Thr209Arg | N* | Arg/Arg vs. Thr/Thr | Arg/Thr vs. Thr/Thr | Arg vs. Thr | Arg/Arg + Arg/Thr vs. | Arg/Arg vs. Arg/Thr + | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Thr/Thr | Thr/Thr | ||||||||||
Homozygous model | Heterozygous model | Allele frequency model | Dominant model | Recessive model | |||||||
OR (95%CI) | PH | OR (95%CI) | PH | OR (95%CI) | PH | OR (95%CI) | PH | OR (95%CI) | PH | ||
Cancer type | |||||||||||
Breast | 4 | 1.04 (0.88, 1.22) | 0.871 | 0.95 (0.84, 1.09) | 0.948 | 1.02 (0.94, 1.11) | 0.925 | 0.98 (0.88, 1.09) | 0.973 | 1.13 (0.97, 1.31) | 0.765 |
Lung | 3 | 0.93 (0.53, 1.62) | 0.563 | 1.15 (0.76, 1.75) | 0.659 | 0.97 (0.73, 1.28) | 0.568 | 1.06 (0.75, 1.50) | 0.679 | 0.96 (0.74, 1.25) | 0.423 |
Other | 10 | 0.94 (0.81, 1.09) | 0.768 | 0.94 (0.83, 1.06) | 0.651 | 0.97 (0.90, 1.04) | 0.906 | 0.96 (0.88, 1.06) | 0.996 | 0.94 (0.83, 1.07) | 0.029 |
Ethnicity | |||||||||||
Caucasian | 13 | 0.99 (0.87, 1.12) | 0.931 | 0.94 (0.85, 1.03) | 0.822 | 0.99 (0.93, 1.06) | 0.928 | 0.97 (0.90, 1.05) | 0.999 | 1.02 (0.93, 1.13) | 0.049 |
Asian | 4 | 0.96 (0.77, 1.19) | 0.525 | 1.02 (0.83, 1.25) | 0.803 | 0.98 (0.87, 1.10) | 0.899 | 1.00 (0.86, 1.16) | 0.971 | 0.94 (0.78, 1.14) | 0.397 |
HWE | |||||||||||
Y | 15 | 0.99 (0.88, 1.10) | 0.970 | 0.95 (0.86, 1.04) | 0.912 | 0.99 (0.93, 1.05) | 0.958 | 0.97 (0.91, 1.05) | 1.000 | 1.01 (0.92, 1.11) | 0.070 |
N | 2 | 0.89 (0.61, 1.31) | 0.171 | 1.06 (0.77, 1.45) | 0.350 | 0.98 (0.81, 1.19) | 0.903 | 1.00 (0.78, 1.29) | 0.689 | 0.94 (0.67, 1.32) | 0.153 |
All | 17 | 0.98 (0.88, 1.09) | 0.949 | 0.95 (0.87, 1.04) | 0.919 | 0.99 (0.94, 1.05) | 0.985 | 0.98 (0.91, 1.05) | 1.000 | 1.01 (0.92, 1.10) | 0.078 |
