Figure 5

Internalization of Cy5.5-exendin-3.
(a,b) Representative sections showing the internalization of the tracer specifically in beta-cells (a) and not in alpha-cells (b). E-cadherin staining is shown in green. Scale bar: 20 μm. (c) Ex vivo signal of the tracer is found in pancreatic islet and in the kidneys. The strong fluorescent intensity in the kidney requires using a pinhole to reject out of focus fluorescence. Scale bar: 200 μm.