Table 2 Effect of vitamin D supplementation on C-peptide (ng/mL) at 3 months and 6 months.
Vitamin D Dose, IU/d | ||||||
|---|---|---|---|---|---|---|
Parameter | Placebo | 1000 | 2000 | 4000 | Mo Change in C-peptide or 25 (OH)D per 1000 IU/d# | P-Value |
n (at baseline) | 81 | 81 | 83 | 83 | ||
Baseline C-Peptide * | 4.46 (0.31) | 4.37 (0.30) | 4.16 (0.27) | 4.49 (0.26) | ||
3 mo C-Peptide | 3.83 (0.21) | 4.31 (0.29) | 4.19 (0.25) | 5.72 (0.44) | ||
6 mo C-peptide | 4.74 (0.30) | 4.07 (0.30) | 4.98 (0.31) | 4.89 (0.49) | ||
Difference C-Peptide (0-3) | −0.44 (0.30) | −0.10 (0.29) | 0 (0.28) | 1.24 (0.38) | 0.42 (0.11) | <0.0001 |
Difference C-peptide (3-6) | 0.75 (0.27) | −0.27 (0.33) | 0.86 (0.27) | −0.74 (0.31) | −0.30 (0.10) | 0.003 |
Difference C-peptide (0-6) | 0.20 (2.59) | −0.35 (2.76) | 0.88 (2.83) | 0.37 (3.71) | 0.10 (0.12) | 0.38 |
Baseline 25(OH)D | 17.07 (1.03) | 17.33 (1.00) | 16.12 (0.98) | 17.64 (0.98) | ||
3 mo 25(OH)D | 14.23 (0.96) | 28.12 (1.12) | 35.48 (1.21) | 47.07 (1.22) | ||
6 mo 25(OH)D | 19.07 (0.99) | 22.26 (0.96) | 26.77 (1.02) | 31.46 (0.81) | ||
Difference 25(OH)D (0-3) | −2.58 (0.66) | 11.01 (1.22) | 19.21 (1.21) | 29.71 (1.30) | 7.73 (0.39) | <0.0001 |
Difference 25(OH)D (3-6) | 4.79 (0.77) | −5.80 (1.10) | −9.20 (0.91) | −15.72 (0.93) | −4.74 (0.32) | <0.0001 |
Difference 25(OH)D (0-6) | 1.83 (0.86) | 5.02 (0.87) | 10.29 (0.95) | 13.82 (0.99) | 3.04 (0.31) | <0.001 |
