Figure 2 | Scientific Reports

Figure 2

From: L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-κB pathway

Figure 2

L-cystathionine inhibited the phosphorylation of NF-κB p65 protein induced by ox-LDL in the THP-1-derived macrophage. The cells were pretreated with L-cystathionine (0.1 mmol/L, 0.3 mmol/L or 1.0 mmol/L, respectively) for 30 min and were then stimulated with 50 mg/L ox-LDL for 30 min. (A) The effect of L-cystathionine on phosphorylation level of NF-κB p65 protein induced by ox-LDL in the THP-1-derived macrophage detected by western blot. (B) The basal phosphorylation level of NF-κB p65 protein in the THP-1-derived macrophage without ox-LDL treatment detected by western blot. L-Cth: L-cystathionine. **P < 0.01 compared with control group, ##p < 0.01 compared with ox-LDL group. Data are presented as mean ± SD (n = 3) of three independent experiments performed in triplicate.

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