Figure 1

(a) HIV-1 protease structure (PDB code: 1T3R) in inhibitor-bound state. HIV-1 protease is shown in purple and cyan colored cartoons for chain A and chain B, respectively. Mutation sites (L10, G48, I54, V82 and I84) are shown in orange colored licorice representation. (b) Structures of APV and DRV inhibitors (key oxygen atoms involved in the protease-inhibitor interactions are labeled with numbers).