Figure 2

(a) Root-mean-square fluctuation (RMSF) vs residue index for apo WT HIV-1 PR and the variants of Flap+and Act (residues in active site, flap and 80s loop are highlighted by black, pink and green circles, respectively). (b–d) Average RMSF of residues in apo WT, Flap+ and Act proteases superposed onto the corresponding crystal structures, with the most (least) variable regions depicted in red (blue).