Figure 6 | Scientific Reports

Figure 6

From: Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir

Figure 6

Time series of the side-chain distance of (a) I50-I84’, (b) I50’-I84, (c) I50-V82’ and (d) I50’-V82 of the apo WT HIV-1 PR and its Flap+and Act variants. Isoleucines in 84 and 84’ positions are replaced by valines in Act, valines in 82 and 82’ are replaced by alanines in Flap+and threonines in Act, respectively. The interactions of these hydrophobic residues in WT HIV-1 PR are shown in left panel.

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