Table 2 The occupancy of the bridging water and the average distances of hydrogen bonds with the bridging water involved for APV and DRV bound HIV-1 PR complex systems.

From: Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir

 

WT-APV

Flap+-APV

Act-APV

WT-DRV

Flap+-DRV

Act-DRV

Occupancy (%)

19.3 ± 4.8

17.2 ± 5.8

24.8 ± 3.9

99.3 ± 1.0

98.7 ± 5.3

26.1 ± 6.4

Average Distance (Å)

3.02 ± 0.38

3.01 ± 0.28

3.00 ± 0.36

2.92 ± 0.19

2.98 ± 0.22

3.01 ± 0.34

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