Figure 2

Fecal microbiota from donor db/db mice confers metabolic benefits of RM in recipient db/db mice.
(a) Alpha-diversity plots showed depletion of gut microbiota by antibiotics treatment in recipient mice prior to fecal microbiota transplantation. P values were calculated by 2-way ANOVA (repeat measure) to be Chao1 (P < 0.0001) or Shannon (P < 0.0001). Fasting glucose (b) and oral glucose tolerance test (OGTT) (c) in recipient db/db mice before (0 month) and after transplantation (1, 2 and 3 months) of fecal microbiota from donor mice (n = 6). Area under curve (AUC) values are also shown. Values are presented as means ± SEM. *p < 0.05, **p < 0.01.