Figure 2

a: ¹³¹I-FA8H1 (200 μCi ) was injected and imaging was performed using a SPECT at various periods to observe in vivo radiolocalization. Solid and hollow black arrows indicate tumors: i, nude mice bearing BEL-7402 (high expression of VEGFR2) at 12 h post-injection; ii, nude mice bearing SMMC-7721 (low expression of VEGFR2) at 12 h post-injection; iii nude mice bearing BEL-7402 at 24 h post-injection; iv, nude mice bearing SMMC-7721 at 24 h post-injection. b and c: Growth curves of tumor volume (b) and final tumor weight (c) for each nude mice-bearing BEL-7402 group (n = 8), indicate a clear relationship between administered activity and response, although significant variability is seen within each group.