Figure 3
a: Histologic changes after RAIT treatment with 131I-FA8H1 or control (hematoxylin-eosin staining, 200-fold magnification) in BEL-7402 xenograft: i, HCC tissue in PBS control group; ii, HCC tissue in FA8H1 group with fibrinoid necrosis; iii, HCC tissue in 131I group with minor coagulative necrosis; iv, HCC tissue in 131I-FA8H1 group with large area of coagulative necrosis. b and c: Immunohistochemical staining of FasL (b) and caspase 3 (c) in HCC tissues after RAIT in nude mice bearing BEL-7402 with 131I-FA8H1 or control (200-fold magnification): i, HCC tissue in PBS control group was negative for FasL and caspase 3; ii, HCC tissue in FA8H1 group, FasL and caspase 3 was detected in a small number of cancer cells; iii, HCC tissue in 131I group with few cancer cells was positive for FasL and caspase 3; iv, HCC tissue in 131I-FA8H1 group with high FasL and caspase 3 expression.
