Table 2 Distribution of MTHFR C677T genotype among cancer cases and controls.
Cases | Controls | HWE (control) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
First Author | Year | Genotyping method | TT | CT | CC | TT | CT | CC | Chi-squre | P |
Weinstein | 2002 | PCR-RFLP | 15 | 53 | 67 | 15 | 62 | 69 | 0.038 | > 0.05 |
Kureshi | 2004 | PCR | 0 | 12 | 22 | 4 | 18 | 32 | 0.420 | > 0.05 |
Capaccio | 2005 | PCR | 14 | 33 | 18 | 18 | 46 | 36 | 0.242 | > 0.05 |
Neumann | 2005 | PCR | 35 | 244 | 258 | 51 | 216 | 278 | 0.914 | > 0.05 |
Vairaktaris | 2006 | PCR-RFLP | 6 | 76 | 28 | 10 | 65 | 45 | 4.065 | < 0.05 |
Hsiung | 2007 | PCR | 149 (a) | - | 128 | 306 (a) | - | 218 | - | - |
Reljic | 2007 | PCR-RFLP | 9 | 27 | 45 | 8 | 59 | 35 | 6.074 | < 0.05 |
Suzuki | 2007 | Taqman | 36 | 113 | 88 | 128 | 331 | 252 | 1.121 | > 0.05 |
Ni | 2008 | PCR-RFLP | 64 | 95 | 48 | 61 | 187 | 152 | 0.078 | > 0.05 |
Siraj | 2008 | PCR | 1 | 18 | 30 | 13 | 126 | 372 | 0.351 | > 0.05 |
Solomon | 2008 | PCR-RFLP | 23 | 55 | 48 | 10 | 42 | 48 | 0.033 | > 0.05 |
Cao | 2010 | PCR-RFLP | 32 | 169 | 310 | 30 | 188 | 334 | 0.275 | > 0.05 |
Kruszyna | 2010 | PCR-RFLP | 10 | 52 | 69 | 20 | 104 | 126 | 0.052 | > 0.05 |
Rodrigues | 2010 | PCR-RFLP | 13 | 43 | 44 | 14 | 40 | 46 | 1.182 | > 0.05 |
Fard-Esfahani | 2011 | Multiplex PCR | 14 | 71 | 69 | 8 | 108 | 82 | 14.224 | < 0.05 |
Prasad | 2011 | PCR-RFLP | 1 | 10 | 86 | 1 | 12 | 228 | 3.311 | > 0.05 |
Sailasree | 2011 | PCR-RFLP | 1 | 8 | 92 | 1 | 29 | 108 | 0.400 | > 0.05 |
Supic | 2011 | PCR-RFLP | 14 | 32 | 50 | 16 | 66 | 80 | 0.193 | > 0.05 |
Tsai | 2011 | PCR-RFLP | 43 | 186 | 391 | 62 | 236 | 322 | 3.606 | > 0.05 |
Galbiatti | 2012 | PCR-RFLP | 45 | 147 | 130 | 55 | 250 | 226 | 1.358 | > 0.05 |
Ozdemir | 2012 | Real-time PCR | 7 | 25 | 28 | 3 | 14 | 33 | 0.781 | > 0.05 |
Vylliotis | 2013 | PCR-RFLP | 6 | 76 | 28 | 10 | 65 | 45 | 4.065 | < 0.05 |
Kweon | 2014 | PCR-RFLP | 422 | 1050 | 722 | 291 | 851 | 527 | 2.748 | > 0.05 |
