Figure 1
From: Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex
Similarity of the top 20-ranked conformations.
Top: the 20 best ranked conformations of the β-arrestin 1/Raf1 complex have been aligned on the β-arrestin (left, β-arrestin shown in surface, Raf in ribbon) and Raf1 (right, Raf shown in surface, β-arrestin in ribbon) partners. Bottom: the residues of β-arrestin (left) and Raf (right) are colored as a function of their presence in the 20 best ranked conformations, from dark red (present in more than 15 out of 20 conformations) to yellow (present in 1 to 4 conformation), grey residues are never in the interface in these 20 conformations. These superimpositions clearly show that the interaction regions on both molecules are highly similar across these 20 conformations.
