Figure 3
From: Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex
Model of the β-arrestin-1/ERK signaling module.
Color code: β-arrestin in grey, c-Src in blue, Raf1 in green, Mek1 in yellow, Erk1 in dark red; experimentally identified residues are in red, other potentially important residues are in orange, phosphorylation sites are in dark blue. A: c-Src/β-arrestin interaction, SH3 domain and its interacting peptide of PDB 1AD5 in violet. B: Raf1/β-arrestin interaction. C: Mek1/β-arrestin interaction. D: Erk1/β-arrestin interaction. E: Mek1/Erk1 interaction. F: Raf1/Mek1 interaction, the region 270-307 figured by a red dashed line is unfolded.
