Table 1 Known interactions in the receptor/β-arrestin/ERK module complex. Interacting amino acids present in the models or compatible are shown in bold, those not found and not easily compatible are shown in italic.
From: Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex
Partner 1 | Partner 2 | Residues/Regions | Ref. and remarks |
|---|---|---|---|
β-arrestin 2 | receptor | L68 V70 L71 L73 V167 L191 S234 Y238 T246 | |
β-arrestin 1 | receptor | Finger, middle and lariat loops | |
β-arrestin 1 | receptor | K77 D78 | |
Receptor | β-arrestin 1/2 | IL2 IL3 | |
Receptor | β-arrestin 1/2 | K265 | |
β-arrestin 1 | c-Src | P91 P121 | |
c-Src | β-arrestin 1 | SH3 domain | |
β-arrestin 1 | Raf1 | R307 | |
β-arrestin 1 & 2 | Raf1 | N-domain C-domain | |
β-arrestin 1 & 2 | MEK1 | N-domain C-domain | |
β-arrestin 1 | MEK1 | D26 D29 | |
MEK1 | β-arrestin 1 | 46-70 R47, K48, R49 | |
β-arrestin 2 | ERK1 | K295 | |
β-arrestin 1 & 2 | ERK1 | N-domain C-domain | |
ERK1 | MEK1 | T202 Y204 | phosphorylated by MEK1 |
MEK1 | Raf1 | 270-307 | |
MEK1 | Raf1 | S218 S222 | 19 phosphorylated by Raf1 |
