Figure 7 | Scientific Reports

Figure 7

From: A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates

Figure 7

ACH-11 exhibited a low bleeding risk in mice.

Fifteen minutes after the administration of ACH-11 (1, 3 and 9 mg/kg), aspirin (9 mg/kg for 30 min) and the vehicle, a 3 mm-long tail tip was cut from the mice and the remaining tail was immersed immediately into saline at 37 °C. The accumulated bleeding time (including periods of re-bleeding) was recorded over a 20-min period. Data are presented as the mean ± SD (n = 10). ****P < 0.0001, **P < 0.01 versus vehicle, analyzed by one-way ANOVA, followed by the Tukey multiple comparison test.

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