Figure 4
Scheme for encoded library synthesis.
a) 2,259 5′-azido-3′-TIPS propargyl tags, Cu(OAc)2, sodium ascorbate, TBTA; b) 2,259 primary amines, NaBH3CN, 60 deg. C; c) TBAF; d) 666 5′-azido-3′-TIPS propargyl tags, Cu(OAc)2, sodium ascorbate, TBTA; e) 3 × 222 bromoaryl acids, DMT-MM f) 669 5′-azido-3′-TIPS propargyl tags, Cu(OAc)2, sodium ascorbate, TBTA; g) 667 boronic acids and esters, Pd(PPh3)4, CsCO3. Remaining 2 wells were encoded nulls and received no reagent or palladium catalyst and no boronate, respectively.
