Figure 5

Neutralization of IL-17A improves survival rate and attenuates sustained inflammation in CLP mice treated with morphine (a) Kaplan–Meier plots of morphine-treated CLP mice injected with isotype control IgG or anti-IL17A antibody. p < 0.01 compared with anti-IL17A-treated mice subjected to CLP (Mantel-Cox log rank test) (b) Bacterial colonies of peritoneal lavage (c) Bacterial colonies of MLN (d) Bacterial colonies of liver *p < 0.05 (Mann-Whitney U test) (Each dot represents one animal) (e) IL-6 concentrations in serum at different time points following CLP. *p < 0.05, **p < 0.01 (Student’s t test) (n = 4) (f) IL-6 concentrations in serum in morphine-treated CLP mice injected with isotype control IgG or anti-IL-17A antibody. **p < 0.01 (Student’s t test) (n = 4).