Table 1 Assessment of protein coding region prediction based on the KNOWN dataset.
From: Revealing Missing Human Protein Isoforms Based on Ab Initio Prediction, RNA-seq and Proteomics
Predictor type | Predictor | Gene | Transcripts | Multiple transcripts per gene | ||
|---|---|---|---|---|---|---|
sensitivity | specificity | sensitivity | specificity | |||
ab initio | ALTSCAN | 41.8% | 24.4% | 17.7% | 3.0% | yes |
Genscanb | 11.3% | 2.2% | 4.1% | 2.2% | no | |
Geneidb | 13.0% | 8.0% | 4.7% | 8.1% | no | |
AUGUSTUS_noRNAa | 16.8% | 14.3% | 6.1% | 14.4% | yes | |
RNA-seq | AUGUSTUS_RNAa | 41.6% | 49.8% | 16.5% | 44.3% | yes |
Exoneratea | 36.1% | 23.3% | 15.3% | 27.3% | no | |
mGenea | 34.6% | 11.2% | 12.6% | 11.3% | yes | |
mGene_grapha | 31.5% | 47.6% | 12.6% | 29.4% | yes | |
mTima | 17.3% | 53.4% | 6.6% | 43.0% | yes | |
NextGeneidASa | 24.8% | 28.8% | 9.6% | 30.9% | no | |
NextGeneidAS ab-initiala | 24.8% | 26.8% | 9.6% | 28.8% | no | |
Transomicsa | 33.4% | 19.9% | 12.2% | 20.2% | no | |
Tromera | 3.5% | 1.5% | 1.3% | 0.6% | yes | |
