Table 1 Trials studying short course radiation in localized rectal cancer.
Study | Regimen | No. of Patients |
|---|---|---|
Stockholm 1 | Arm 1: 5×5 Gy with immediate surgery | 424 |
Arm 2: surgery alone | 425 | |
Stockholm 2 | Arm 1: 5 ×5 Gy with immediate surgery | 272 |
Arm 2: surgery alone | 285 | |
Swedish trial | Arm 1: 5×5 Gy with immediate surgery | 585 |
Arm 2: surgery alone | 583 | |
Uppsala | Arm 1: 5 ×5.1 Gy with immediate surgery | 235 |
Arm 2: selective postoperative radiotherapy for patients with stage B/C, 60 Gy in 30 fr | 236 | |
Dutch TME trial | Arm 1: 5 ×5 Gy with immediate surgery | 924 |
Arm 2: selective postoperative radiotherapy for patients with positive margins (11%), 50.4 Gy in 28 fr | 937 | |
MRC CR07 | Arm 1: 5 ×5 Gy with immediate surgery | 674 |
Arm 2: selective postoperative CRT for patients with positive circumferential margin(9%), 45 Gy in 25 fr +5-FU | 676 | |
Polish trial | Arm 1: 5 ×5 Gy with immediate surgery | 155 |
Arm 2: 50.4 Gy in 28 fr with concomitant CT weeks 1 & 5 | 157 | |
TROG 01.04 | Arm 1: 5 ×5 Gy with immediate surgery | 163 |
Arm 2: 50.4 Gy and 5-FU 225 mg/m2/day followed by surgery at 4-6 weeks | 163 |
