Figure 3
Effect of the L-citrullin on ADMA-induced reduction of eNOS expression, eNOS phosphorylation and ASS expression in PCA.
Both (a) mRNA and (b) protein levels of eNOS were down-regulated after 24 h ADMA exposure and such down-regulation was restored by L-citrulline. (c) L-citrulline enhanced eNOS phosphorylation at Ser1177 site that was decreased by ADMA. (d) the expression of ASS protein was also unregulated by L-citrulline. Data are shown as mean ± SEM. (**p < 0.01, vs. control group. * p < 0.05, vs. control group. # p < 0.05, vs. ADMA group. n = 3, one-way ANOVA).
