Figure 5
Effect of L-citrulline on ADMA-induced reduction of cGMP level in PCA.
(a) the cGMP level of PCA rings without endothelium (E-) was significant lower than that with endothelium (E+). The L-citrulline could not affect the cGMP level in in PCA rings without endothelium (E-) after 24 h incubation. (b) the cGMP level was significantly decreased after 24 h ADMA exposure, which was partially normalized by L-citrulline. Data are shown as mean ± SEM. (* p < 0.05, vs. control group. # p < 0.05, vs. ADMA group. n = 3, one-way ANOVA).
