Table 3 Comparison of neurological soft signs and neuropsychological function performances between patients with schizophrenia and healthy controls at baseline assessment.

From: Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances

 

Patients with Schizophrenia

 

Analysis a

Cohen’s d

 

Prominent Negative Symptoms (PNS,N = 29)

Non-Prominent Negative Symptoms (NPNS, N = 116)

Health controls (HC, N = 62)

F

P

PNS vs NPNS

PNS vs HC

NPNS Vs HC

CNI

Total scores

7.13 (3.17)

5.61 (3.07)

2.76 (2.21)

19.02

<0.001

0.49

1.60

1.07

Motor coordination

3.68 (1.98)

2.64 (1.88)

1.34 (1.28)

13.47

<0.001

0.54

1.40

0.81

Sensory Integration

2.26 (1.50)

1.99 (1.40)

0.74 (1.13)

12.41

<0.001

0.19

1.14

0.98

Disinhibition

1.19 (0.97)

0.98 (0.93)

0.68 (0.65)

3.21

0.042

0.22

0.62

0.37

Neuropsychological functions

LM immediate score

6.93 (3.77)

8.41 (3.50)

11.19 (3.47)

11.45

<0.001

−0.41

−1.18

−0.80

LM delayed score

4.83 (3.01)

6.56 (3.67)

9.69 (4.08)

13.87

<0.001

−0.52

−1.36

−0.81

VR immediate score

19.66 (3.82)

20.77 (2.51)

21.97 (1.98)

4.23

0.016

−0.34

−0.76

−0.53

VR delayed score

19.62 (4.50)

20.28 (2.74)

21.44 (2.01)

2.29

0.104

−0.18

−0.52

−0.48

LN span correct items

13.96 (2.89)

15.50 (3.25)

17.84 (3.40)

5.85

0.003

−0.50

−1.23

−0.70

LN span longest items

5.46 (0.95)

6.00 (1.09)

6.68 (1.21)

4.04

0.019

−0.53

−1.12

−0.59

Verbal fluency

17.24 (4.97)

18.04 (5.06)

21.63 (5.51)

5.21

0.006

−0.16

−0.84

−0.68

WSCT perseverative errors

3.18 (3.39)

2.68 (3.10)

0.76 (1.40)

2.70

0.069

0.15

0.93

0.80

WSCT category score

4.85 (1.41)

5.15 (1.41)

5.76 (0.88)

6.42

0.002

−0.22

−0.77

−0.52

  1. CNI: Cambridge Neurological Inventory; LM: Logical Memory; VR: Visual Reproduction; LNS: Letter-Number Span Test; PNS: prominent negative symptoms; NPNS: non-prominent negative symptoms; WCST: Wisconsin Card Sorting Test; a, MANCOVA (Multivariate analysis of covariance) gender and IQ as covariates.