Figure 7 | Scientific Reports

Figure 7

From: Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model

Figure 7

In vivo effects of edaravone and diethyl maleate (DEM) treatments of human umbilical cord mesenchymal stem cells (hUCMSCs) on their therapeutic efficacy in an acute liver failure model induced by D-galactosamine/LPS (Gal/LPS).

(a) Edaravone treatment showed better rescuing effects on NOD/SCID mice death than untreated and DEM-treated hUCMSCs. (b,c) Edaravone treatment showed better ameliorative effects on hepatic histology than untreated and DEM-treated hUCMSCs after liver failure. Yellow arrows indicate typical necro-inflammatory cells. (d) Edaravone increased while DEM decreased the expanded cell number in the host liver after transplantation. (e) Localization of hUCMSCs in the Gal/LPS-challenged mouse liver using PKH immunofluorescnece at day 7 post-infusion. Quantified data also proved the finding. GL, Gal/LPS. Magnification 200x. Bar: 20 μm. “*” “**” “***” mean significant changes (P < 0.05, 0.01, 0.001) between indicated two groups, respectively.

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