Figure 3
From: DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria
DW-F5 down-regulates activation of survival signals.
(a) DW-F5 drastically inhibits the BRAF expression in A375 cells. (b) DW-F5 down-regulates the constitutive and PMA-induced phosphorylation of ERK1/2. (c-e) DW-F5 down-regulates Brn-2, β-catenin and MITF-M. (f) DW-F5 down-regulates constitutive and PMA-induced phosphorylation of Akt. (g,h) DW-F5 down-regulates nuclear translocation of NF-кB. (i,j) DW-F5 down-regulates constitutive and PMA-induced up-regulation of COX-2 and Bcl-2. (k,l) DW-F5 down-regulates VEGF and MMPs. The details of treatment modes are provided in SI methods.
