Table 1 Upregulation and downregulation proteins list (Ratio ≥ 1.80 or p-value < 0.05*), SI = spectral index Asterisks indicate proteins with ratios that were significantly different from 1 (one-sample t-test, p < 0.05*).

From: Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

IPI

GENE SYMBOL

Sequencecoverage (%)

No ofpeptide

AD(SI)

WT(SI)

AverageFold Change (AD/WT)

Adjustedp-value

IPI

GENESYMBOL

Sequencecoverage (%)

No ofpeptide

AD(SI)

WT(SI)

AverageFold Change (AD/WT)

Adjustedp-value

Upregulaton proteins

IPI00470912

C2orf16*

9.0

12

7.53

0.00

n.a

0.00982

IPI01018212

PKM2

22.2

34

6.87

2.92

2.35

0.01708

IPI00216864

PDZRN4*

9.5

16

5.28

0.00

n.a

0.00731

IPI00333696

HEATR5B

7.8

21

5.72

2.43

2.35

0.01892

IPI00876841

ZSWIM8 *

4.6

9

4.23

0.25

16.72

0.01489

IPI00069084

TRRAP

2.3

18

3.73

1.64

2.28

0.01892

IPI00219446

PEBP1*

28.6

10

3.30

0.24

13.96

0.00040

IPI00943735

ANKRD36

6.3

10

3.15

1.38

2.28

0.01892

IPI00871535

SPTAN1

3.0

13

9.35

1.01

9.24

0.01892

IPI00642259

DST

2.1

29

12.91

5.72

2.26

0.01899

IPI00964552

COL12A1*

5.4

28

6.88

0.97

7.08

0.00444

IPI00218474

ENO3

14.7

14

2.17

0.98

2.21

0.01892

IPI00084828

STXBP1*

11.8

9

3.78

0.57

6.67

0.01588

IPI00549725

PGAM1

17.5

9

3.78

1.74

2.17

0.01892

IPI00413144

C15orf42

6.2

10

8.22

1.27

6.48

0.01766

IPI00291006

MDH2

27.9

25

11.18

5.21

2.15

0.01892

IPI01014674

MUC19*

31.6

11

10.22

1.89

5.41

0.01349

IPI00414123

CRMP1

10.9

6

0.99

0.46

2.14

0.02350

IPI00954159

AHCTF1P1

6.0

20

8.06

1.52

5.31

0.01856

IPI00025363

GFAP

61.1

195

38.93

18.50

2.10

0.01856

IPI00382470

HSP90AA1

7.2

8

5.18

1.01

5.11

0.01892

IPI00550232

XIRP2

3.6

18

6.33

3.09

2.05

0.01892

IPI00169383

PGK1

14.9

4

3.22

0.67

4.79

0.01839

IPI00045512

HMCN1

3.2

30

6.90

3.39

2.04

0.01892

IPI00879193

TTC28

5.1

13

6.89

1.46

4.73

0.01856

IPI00006091

DMD

3.3

9

5.55

2.73

2.03

0.01899

IPI00007188

SLC25A5

18.6

5

1.00

0.22

4.57

0.01856

IPI00215715

CAMK2A

13.5

14

4.42

2.18

2.03

0.01892

IPI00884904

AHNAK2

3.4

15

10.25

2.79

3.67

0.01892

IPI00930130

TUBB6

48.0

107

1.92

0.95

2.02

0.01892

IPI01011955

MKI67

7.2

21

5.33

1.53

3.49

0.01892

IPI00419908

GPR179

4.9

9

4.24

2.10

2.02

0.02350

IPI00218658

ITPR1

5.8

13

4.20

1.27

3.31

0.01856

IPI00171636

NAV1

5.8

10

3.76

1.92

1.95

0.01892

IPI00328089

HIVEP3*

6.4

17

8.16

2.53

3.22

0.01203

IPI01015973

MUC16

8.6

233

7.47

3.87

1.93

0.01892

IPI00413173

MKI67

3.4

10

10.05

3.52

2.85

0.01856

IPI00004233

MKI67

7.2

21

9.39

4.93

1.90

0.02167

IPI00411656

PCLO*

3.2

26

16.37

5.81

2.82

0.01588

IPI00925013

MLL3*

12.5

26

8.01

4.25

1.89

0.01689

IPI00740909

ALMS1

4.5

21

6.37

2.28

2.80

0.01856

IPI00218621

SON

7.6

98

7.24

3.86

1.87

0.02078

IPI00398002

PLEC

4.1

28

7.85

3.00

2.61

0.01892

IPI00329573

COL12A1

7.2

30

5.12

2.79

1.84

0.01932

IPI00789624

PCLO

6.7

40

13.14

5.08

2.59

0.01839

IPI00797574

BOD1L

5.9

23

11.54

6.38

1.81

0.01856

IPI00749231

GPR98

3.5

17

3.19

1.24

2.58

0.01892

IPI00021907

MBP

32.2

41

5.19

2.88

1.80

0.02579

IPI00289776

MYCBP2

4.2

18

13.60

5.49

2.48

0.01892

        

IPI00169307

ARHGAP21*

6.3

27

7.77

3.17

2.45

0.01489

        

IPI00854820

PPRC1

6.6

14

2.86

1.18

2.42

0.01892

        

IPI00215631

VCAN

4.0

21

4.29

1.79

2.39

0.01892

        

IPI00102752

RBM15

7.6

20

4.99

8.89

0.56

0.01892

IPI00788168

MAST4

3.5

8

1.23

3.12

0.39

0.01892

IPI00014845

DNAH8

3.9

29

2.63

4.73

0.56

0.01892

IPI00908811

CKB

32.3

26

1.05

2.69

0.39

0.01892

IPI00217051

NAV3

11.7

33

8.65

15.58

0.56

0.01892

IPI00006451

NSF

5.0

4

1.01

2.58

0.39

0.01892

IPI00044608

PLIN4

17.2

30

7.38

13.38

0.55

0.01892

IPI00031411

FAT1

3.0

17

2.66

7.08

0.38

0.01892

IPI00854629

OBSCN

2.3

33

3.83

6.97

0.55

0.01892

IPI00983524

MBP

58.6

59

0.62

1.76

0.35

0.01856

IPI00221325

RANBP2

5.3

14

3.98

7.24

0.55

0.02154

IPI00445401

HUWE1*

5.6

27

2.39

6.99

0.34

0.01203

IPI00868928

KIF26B

5.5

19

3.45

6.39

0.54

0.01892

IPI00257508

DPYSL2*

23.3

27

3.22

10.01

0.32

0.01203

IPI01018628

UTY

11.6

24

5.10

9.47

0.54

0.01892

IPI00021263

YWHAZ*

17.0

12

0.84

2.65

0.32

0.01489

IPI00018352

UCHL1

19.2

10

1.77

3.30

0.53

0.01892

IPI00479743

POTEE

14.1

40

0.82

2.75

0.30

0.01892

IPI00815697

NAV2

12.0

31

2.12

4.00

0.53

0.02549

IPI01019113

TUBB

49.6

155

0.23

0.79

0.30

0.01756

IPI00003935

HIST2H2BE

19.0

9

1.27

2.39

0.53

0.01892

IPI00006510

TUBB1

11.7

11

0.29

0.99

0.30

0.01892

IPI00008161

ATP12A

5.9

12

0.77

1.46

0.53

0.01892

IPI01019105

UTY

4.7

10

1.29

4.57

0.28

0.01892

IPI00018511

TUBB4Q

11.7

12

0.51

0.98

0.52

0.01977

IPI00478021

DNAH8*

4.0

29

2.06

7.68

0.27

0.01676

IPI00952742

SHANK2

4.6

14

2.05

4.00

0.51

0.01892

IPI00217002

KIAA2018

7.2

11

1.48

5.65

0.26

0.01856

IPI00297593

USP34

4.0

25

3.75

7.30

0.51

0.01892

IPI00853390

GPR112*

5.8

34

1.84

7.91

0.23

0.00982

IPI00306457

FNDC1

9.4

10

2.74

5.42

0.51

0.01892

IPI00443415

MCC*

5.5

9

0.99

4.32

0.23

0.01203

IPI00019848

HCFC1

7.5

15

3.51

6.95

0.51

0.02078

IPI00956686

ATXN7*

15.6

11

0.88

4.54

0.19

0.01203

IPI00914628

USP24

4.5

9

1.76

3.48

0.50

0.02135

IPI00157790

KIAA0368

4.2

7

0.99

5.17

0.19

0.01856

IPI00026320

UBR5

5.1

15

6.07

12.42

0.49

0.01892

IPI00220717

RBM15*

7.6

20

1.03

5.64

0.18

0.00731

IPI00215877

APC

7.6

41

3.85

7.89

0.49

0.01892

IPI00795015

SACS*

1.9

15

0.99

5.78

0.17

0.00731

IPI00946001

ONECUT2

26.8

15

3.48

7.17

0.49

0.01891

IPI00738216

KIAA0947*

7.1

15

0.62

3.82

0.16

0.01203

IPI00298994

TLN1

6.9

18

4.76

9.93

0.48

0.01856

IPI00642705

ARID1A*

7.7

25

1.33

8.27

0.16

0.00731

IPI00914890

MAST4

3.3

8

1.17

2.47

0.47

0.02154

IPI01014270

APOB

4.6

21

1.33

9.55

0.14

0.01856

IPI00788188

DYNC2H1

5.4

24

2.83

6.05

0.47

0.01892

IPI00740545

POTEI*

11.2

26

0.21

1.54

0.14

0.00507

IPI00007750

TUBA4A

37.4

56

0.55

1.19

0.46

0.01856

IPI00790327

ATP1A3*

8.7

27

0.40

4.10

0.10

0.01489

IPI00026272

HIST1H2AE

21.8

6

0.76

1.67

0.46

0.01892

IPI00879810

SPTAN1

5.3

18

1.00

10.50

0.10

0.01892

IPI00985241

MBP

67.5

59

1.00

2.21

0.45

0.01892

IPI00917728

NEB*

3.7

58

0.80

9.19

0.09

0.00549

IPI00215628

VCAN

5.5

9

1.17

2.75

0.43

0.02109

IPI00871227

HMCN1*

3.1

15

0.29

4.56

0.06

0.01203

IPI00643465

TACC2

3.2

7

1.17

2.76

0.42

0.01892

IPI00386035

FLG*

11.7

21

0.00

6.61

n.a

0.00731

IPI00179298

HUWE1*

5.6

43

4.55

10.74

0.42

0.01708

IPI00012645

SPTBN2*

5.9

10

0.00

6.66

n.a

0.00741

IPI00847978

FAT3

1.0

13

2.56

6.06

0.42

0.02078

        
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